How can I permanently prevent option positions from being exercised?

There is no way to enter permanent instructions to avoid being auto exercised for expiring In-the-Money long options.  You need to sell to close your long open option position before it stops trading on the option's Last Trade date to avoid being auto exercised if a long option expires In-the-Money.  The OCC Options Clearing Corp's auto exercise threshold is 0.01 USD In-the-Money as compared to the closing price of the underlying.  If your option appears that it may finish In-the-Money at expiration and you do not want to take delivery of the underlying this one time then you can use the IB Option Exercise/Lapse tool to enter contrary instructions and "Lapse" your option and not take delivery of the underlying.  The IB Knowledge Base article for How can I exercise or lapse a long option outlines how this is done in the TWS/Mosaic. The IBKR Mobile phone and tablet Option Exercise/Lapse feature can be found in the Menu window for Option/Exercise then after selecting an option there is a choice to "Allow lapsing in-the-money".   

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What happens to my options spread at expiration?
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Can you exercise the out-of-the-money long leg of my spread position only if my in-the-money short leg is assigned?