Can I trade cryptocurrency in the Paxos web app and also through IBKR trading platforms?

Once you enable Crypto Plus trading permissions, you can elect to trade BTC, ETH, LTC and BCH cryptocurrencies using the original TWS paradigm. All other cryptocurrencies offered by the Cryptocurrency Service Providers must be traded via the Cryptocurrency Service Provider's Web App.  However, once you have enabled Crypto Plus trading permissions, all crypto trades regardless of the platform on which they originate will require pre-funding. 

All exchange and custody services in connection with trading and holding cryptocurrency tokens and other digital asset tokens through IBKR trading platforms are provided by Cryptocurrency Service Providers. Learn more.

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What is the difference between Crypto Basic and Crypto Plus trading permissions?
Can I trade cryptocurrencies when the IBKR system is unavailable?
What does "pre-fund" my account for cryptocurrency trading mean?